{"product_id":"borna-virus-rt-qpcr","title":"Borna virus, RT-qPCR","description":"\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003ePathogen test \u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cstrong\u003eThe RT-cPCR test\u003c\/strong\u003e\u003c\/span\u003e\u003cspan class=\"s1\"\u003e detects the\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e\u003cstrong\u003egenome (RNA)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eof Borna virus.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eSample\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e5 mL - blood - K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eand\/or\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e5mL - liquor (CSF) - sterile tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eTurnaround time\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e2 to 5 working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"p1\"\u003e \u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cstrong\u003e\u003cspan class=\"s1\"\u003eWhat is Borna virus?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cspan class=\"s1\" style=\"color: #000000;\"\u003eBorna disease is caused by one of just a few bornaviruses that occur in a wide variety of warm-blooded animals. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cspan class=\"s1\" style=\"color: #000000;\"\u003eThis virus attacks the nerve cells within the brain itself causing dangerous levels of inflammation. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cspan class=\"s1\" style=\"color: #000000;\"\u003eThis virus is frequently lethal once symptoms begin presenting themselves, however, antibodies specific to the virus have frequently been found in the blood of animals who are clinically unaffected. This suggests that some horses and other animals may become infected and remain asymptomatic. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cspan class=\"s1\" style=\"color: #000000;\"\u003eBorna disease is a rare viral infection that causes swelling of the nerve cells in the brain, leading to unusual behaviours and seizures, and is frequently fatal.\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"s1\"\u003eClinical signs\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe clinical signs of Borna disease usually occur in horses two to three months after the initial exposure, although there have been reports of incubation periods exceeding six months. \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBlindness\u003c\/li\u003e\n\u003cli\u003eChewing motions \u003c\/li\u003e\n\u003cli\u003eColic symptoms\u003c\/li\u003e\n\u003cli\u003eCollapse\u003c\/li\u003e\n\u003cli\u003eHead-pressing\u003c\/li\u003e\n\u003cli\u003eHypersensitivity\u003c\/li\u003e\n\u003cli\u003eLack of coordination\u003c\/li\u003e\n\u003cli\u003eLeaning \u003c\/li\u003e\n\u003cli\u003eLoss of appetite\u003c\/li\u003e\n\u003cli\u003eMuscular tremors\u003c\/li\u003e\n\u003cli\u003eParalysis Rapid and involuntary eye movement\u003c\/li\u003e\n\u003cli\u003eSawhorse stance\u003c\/li\u003e\n\u003cli\u003eSevere depression\u003c\/li\u003e\n\u003cli\u003eWeakness \u003c\/li\u003e\n\u003cli\u003eYawning\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eTransmission\u003c\/strong\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe virus that causes Borna disease in horses is closely related to the bornavirus that affects birds and is believed to be the cause of  Proventricular Dilatation Disease (PDD) in birds. \u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe transmission methods for these viruses are not well understood, but direct contact with either saliva or nasal secretions are believed to be a common vector. \u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBorna disease emerges more frequently on farms with poor rodent control and hygiene, and instances seem to peak during the months between March to June.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePrevention\u003c\/strong\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cul\u003e\n\u003cli\u003eExperimental vaccines for immunopathology have had mixed results. In some cases, the immunopathology of the infection caused some vaccines to exacerbate the disease, but recent evidence suggests the possibility of effective inoculation.\u003c\/li\u003e\n\u003cli\u003eAlthough some preliminary research indicates success with protective vaccination of mice, at this writing, no pre-exposure vaccine has been developed for use with horses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment\u003c\/strong\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe antiviral drug amantadine sulfate may be a potential treatment for Borna disease virus. It has been demonstrated in vitro to inhibit wild-type BDV replication and spread of infection. \u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAs with prevention of the disease, much research is needed to develop successful treatment strategies because, currently, the fatality rate ranges between 60 to 95 percent for horses, and animals that survive often remain neurologically impaired permanently.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":29397171896364,"sku":"","price":61.5,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/products\/Borna_virus.png?v=1665065787","url":"https:\/\/www.equigerminal.org\/ar\/products\/borna-virus-rt-qpcr","provider":"Equigerminal","version":"1.0","type":"link"}