{"product_id":"cerebellar-abiotrophy","title":"Cerebellar abiotrophy - CA","description":"\u003cdiv\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eDNA test\u003c\/strong\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cstrong\u003eDNA test\u003c\/strong\u003e for the Cerebellar Abiotrophy (CA) – Pure and part-bred Arab horses. This\u003c\/span\u003e\u003cspan class=\"s1\"\u003e test verifies the presence of the recessive CA mutation.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eSample\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e30 to 40 - hair roots - envelope\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cspan\u003eor\u003c\/span\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e5 mL - blood - K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eTurnaround time\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e2 to 5  working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cimg alt=\"\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/F_ISAG_MEMBER_small.jpg?v=1563820312\" style=\"float: none;\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cstrong\u003eWhy test?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan class=\"s1\"\u003eThis DNA test determines CA clear, carrier or affected status. Informed choices can be made for breeding selections, and prevent the born of affected foals.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eCA is sometimes confused with Wobbler’s syndrome, Equine Protozoal Myeloencephalitis (EPM) and injury-related problems, such as a concussion, so this DNA test could help on the diagnostic.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #00afab;\"\u003e\u003cstrong\u003eResults description\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003cspan class=\"s1\"\u003eThe DNA test verifies the presence of the recessive CA mutation and presents results as one of the following:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eN\/\u003c\/b\u003e –\u003cstrong\u003e Negative for CA\u003c\/strong\u003e. Absence of the allele responsible for CA.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eN\/CA\u003c\/strong\u003e \u003cstrong\u003e– Carrier - Positive heterozygous for CA.\u003c\/strong\u003e Presence of one copy of the allele responsible for CA.\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eThe horse is a carrier for CA disorder and can pass on a copy of CA allele to 50% of their progeny when bred.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCA\/\u003c\/strong\u003e–\u003cstrong\u003e Affected - Positive Homozygous for CA\u003c\/strong\u003e. Presence of two copies of the allele responsible for CA.\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eThe horse is affected by\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eCA disorder and can pass the CA allele to 100% of their progeny when bred.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCerebellar Abiotrophy (CA), is a genetic neurological disease in certain species of animals.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThe disorder manifests itself when Purkinje cells, the neurons that affect balance and coordination, are present in the cerebellum of the brain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThis condition known to affect Arabian horses as well as Miniature horses, the Gotland Pony and possibly the Oldenburg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eIn most cases, foals appear normal at birth, and symptoms generally become noticeable after four months. There have been reported cases where the condition was observed shortly after birth, while others report symptoms developing after the first year.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHorses affected with CA tend to startle easily and often fall. Common symptoms include head tremor, a lack of balance and other neurological issues.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAffected horses may develop a wide-based stance of the forelegs and difficulty rising from a reclining position. In horses, CA is believed to be linked to an autosomal recessive gene. This means that it is not sex-linked and the allele has to be carried and passed on by both parents in order for an affected animal to be born.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHorses that only carry one copy of the gene may pass it on to their offspring, despite being perfectly healthy themselves and having no symptoms of the disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eBecause the disorder is recessive, the allele for CA may pass through multiple generations before it is expressed.\u003c\/span\u003e\u003c\/p\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":29451250958380,"sku":"","price":43.05,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/products\/Cerebellar_Ab.png?v=1665065799","url":"https:\/\/www.equigerminal.org\/eu\/products\/cerebellar-abiotrophy","provider":"Equigerminal","version":"1.0","type":"link"}