{"product_id":"congenital-myotonia-cm","title":"Congenital Myotonia - CM","description":"\u003cdiv\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eDNA test for the Congenital Myotonia (CM). \u003c\/span\u003e\u003cspan class=\"s1\"\u003eThis test verifies the presence of the recessive \u003cem\u003ecm\u003c\/em\u003e gene.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eSample \u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e30 to 40 hair roots\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cspan\u003eor\u003c\/span\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e5 mL of blood in a K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eTurnaround time\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e2 to 5  working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cimg style=\"float: none;\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/F_ISAG_MEMBER_small.jpg?v=1563820312\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cstrong\u003eWhy test?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan class=\"s1\"\u003eThis genetic test helps breeders to identify horses that carrying the \u003cem\u003ecm\u003c\/em\u003e recessive mutation. \u003c\/span\u003eInformed choices can be made for breeding selections, and prevent the born of affected foals.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #00afab;\"\u003e\u003cstrong\u003eResults description\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThe DNA test verifies the presence of the recessive \u003cem\u003ecm\u003c\/em\u003e gene and presents results as one of the following:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003eN\/ -\u003c\/b\u003e \u003c\/span\u003e\u003cstrong\u003eNormal\u003c\/strong\u003e\u003cspan class=\"s2\"\u003e for Congenital Myotonia (CM).\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eAbsence of the affected variant responsible for Congenital Myotonia\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eN\/cm \u003c\/strong\u003e- \u003cstrong\u003eCarrier \u003c\/strong\u003eof Congenital Myotonia (CM). Presence of one copy of the genetic variant causative of Congenital Myotonia. The horse is \u003cspan class=\"s3\"\u003eclinical healthy \u003c\/span\u003e\u003cspan class=\"s2\"\u003eand can pass the genetic variant responsible for CM to 50% of their progeny when bred.\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003ecm\/ - Affected\u003c\/strong\u003e\u003c\/span\u003e\u003cspan class=\"s2\"\u003e\u003cspan style=\"color: #000000;\"\u003e by CM. Presence of two copies of the genetic variant causativ\u003c\/span\u003ee of Congenital Myotonia. The horse is \u003c\/span\u003e\u003cspan class=\"s3\"\u003eaffected \u003c\/span\u003e\u003cspan class=\"s2\"\u003ewith Congenital Myotonia and will pass genetic variant to 100% of its offspring.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan class=\"s1\"\u003eCongenital Myotonia is an inherited neuromuscular disorder characterised by the slow relaxation of muscles after voluntary contraction or electrical stimulation.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eThis disorder has been identified in New Forest ponies and it is caused by an autosomal recessive mutation, which is responsible for the function of chloride ion channels in the skeletal muscle.\u003c\/li\u003e\n\u003cli\u003eCarriers of the mutation appear normal, but when two carriers are mated, a 25 percent chance exists that an affected foal will be produced.\u003cspan class=\"s1\"\u003e \u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003eAffected foals appear normal at birth. The first symptoms are recurrent episodes of recumbency and difficulty rising to its feet as a result of muscle stiffness. They occur during the first weeks of age and usually increase in the following months.\u003c\/li\u003e\n\u003cli\u003ePicking up the limbs is not possible because of the muscle rigidity. The eye-bulb may be retracted due to the myotonia.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":29451405819948,"sku":"","price":43.05,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/products\/Myotonia_C..png?v=1571094917","url":"https:\/\/www.equigerminal.org\/eu\/products\/congenital-myotonia-cm","provider":"Equigerminal","version":"1.0","type":"link"}