{"product_id":"polysaccharide-storage-myophaty-type-2-pssm2","title":"MIM (PSSM2) DNA Test - 6 variant panel","description":"\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cmeta content=\"width=device-width, initial-scale=1.0\" name=\"viewport\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e\n        body {font-family: Arial, sans-serif; line-height: 1.6; background-color: #f9f9f9; color: #333; margin: 0; padding: 0;}\n        .content {padding: 20px;}\n        h2 {color: #E11BE9; margin-top: 20px;}\n        h3 {color: #119EC2; margin-top: 20px;}\n        ul {list-style-type: square; padding-left: 20px;}\n        .toggle-btn {display: inline-block; margin-top: 10px; padding: 10px 20px; background-color: #119EC2; color: white; text-align: center; text-decoration: none; border-radius: 5px; cursor: pointer;}\n        .toggle-btn:hover {background-color: #0b7a96;}\n        .highlight {background-color: #f3e5f5; padding: 10px; border-left: 4px solid #E11BE9; margin-bottom: 20px;}\n        .expandable {display: none; margin-top: 20px;}\n        .shaded-box {background-color: #f9f9f9; border: 1px solid #ddd; padding: 15px; border-radius: 5px; box-shadow: 0 2px 4px rgba(0,0,0,0.1); margin-bottom: 20px;}\n        .section-title {color: #E11BE9; padding: 10px; margin-bottom: 10px; font-size: 1.2em;}\n    \u003c\/style\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"content\"\u003e\n\u003ch2\u003eMIM (PSSM2) DNA Test\u003c\/h2\u003e\n\u003cdiv class=\"highlight\"\u003e\n\u003cp\u003e\u003cstrong\u003eEnsure the Health and Performance of Your Horses with Accurate MIM Testing.\u003c\/strong\u003e Our DNA test identifies the presence of genetic variants associated with Muscle Integrity Myopathy (MIM), formerly known as PSSM2, which affects muscle function and structure.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSample Requirements\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003e30 to 40 hair roots - envelope\u003c\/li\u003e\n\u003cli\u003eAlternatively, 5 mL blood - K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eTurnaround Time\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003eup to 15 working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eResults Description\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe DNA test identifies six genetic variants that predispose horses to developing symptoms of Muscle Integrity Myopathy:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eP2:\u003c\/strong\u003e Myotilinopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP3:\u003c\/strong\u003e Filaminopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP4:\u003c\/strong\u003e Myozenin-3-Myopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP8:\u003c\/strong\u003e PYROXD1-Myopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePx:\u003c\/strong\u003e CACNA2D3-Myopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eK1:\u003c\/strong\u003e COL6A3-Myopathy\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eGenetic Inheritance\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eMuscle Integrity Myopathy (MIM) is caused by a hereditary predisposition involving multiple genetic variants. These variants disrupt the structure and function of muscle fibers, leading to symptoms such as muscle stiffness, unexplained lameness, and difficulty building muscle.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eClinical Signs and Affected Breeds\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eSymptoms of MIM can vary widely among horses and include unexplained lameness, muscle stiffness, difficulty with gait changes, reluctance to move, muscle atrophy, and behavioral changes. Almost any breed can be affected, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eWhy Test?\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cp\u003eTesting for MIM is crucial for breeders and owners to make informed decisions. By identifying carriers of the genetic variants, breeding choices can be optimized to prevent the spread of these disorders. Additionally, knowing a horse's genetic status can help manage and mitigate symptoms through tailored exercise and feeding protocols.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ca class=\"toggle-btn\" onclick=\"toggleSection('learn-more-content')\"\u003eLearn More\u003c\/a\u003e\n\u003cdiv id=\"learn-more-content\" class=\"expandable\"\u003e\n\u003ch3 class=\"section-title\"\u003eDetailed Results Description\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe DNA test results will indicate the presence of the following genetic variants:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eP2:\u003c\/strong\u003e Myotilinopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP3:\u003c\/strong\u003e Filaminopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP4:\u003c\/strong\u003e Myozenin-3-Myopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP8:\u003c\/strong\u003e PYROXD1-Myopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePx:\u003c\/strong\u003e CACNA2D3-Myopathy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eK1:\u003c\/strong\u003e COL6A3-Myopathy\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"section-title\"\u003eAdditional Information\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eMuscle Integrity Myopathy (MIM) is a genetic disorder that disrupts muscle function and structure, leading to various clinical signs. While it is not possible to cure genetic disorders, optimized management through diet and exercise can help mitigate symptoms, allowing horses to lead normal lives.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"section-title\"\u003eReferences\u003c\/h3\u003e\nGeneratio. \u003ca href=\"https:\/\/www.generatio.de\/mim-pssm2\" target=\"_blank\"\u003eMuscle Integrity Myopathy in Horses\u003c\/a\u003eEquiSeq. \u003ca href=\"https:\/\/www.equiseq.com\/learn_pssm2\" target=\"_blank\"\u003ePolysaccharide Storage Myopathy type 2 (PSSM2)\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003ca class=\"toggle-btn\" onclick=\"toggleSection('faq-content')\"\u003eCheck our FAQs for more information\u003c\/a\u003e\u003c\/p\u003e\n\u003cdiv id=\"faq-content\" class=\"expandable\"\u003e\n\u003ch3 class=\"section-title\"\u003eFAQs\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eWhat breeds are affected by MIM?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAlmost any breed can be affected by MIM, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow is MIM inherited?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMIM is caused by multiple genetic variants that disrupt muscle structure and function. These variants are inherited and can predispose horses to developing symptoms of exertional myopathy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow can MIM be managed?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile genetic disorders cannot be cured, their symptoms can often be managed through optimized feeding and exercise protocols. Identifying genetic variants through testing allows for tailored management strategies to mitigate symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/equigerminal.shop\/pages\/faqs\" target=\"_blank\"\u003eVisit our full FAQ page\u003c\/a\u003e for more details.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Generatio","offers":[{"title":"Default Title","offer_id":29451457724460,"sku":"","price":357.32,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/MIMPSSM2.png?v=1716904823","url":"https:\/\/www.equigerminal.org\/tr\/products\/polysaccharide-storage-myophaty-type-2-pssm2","provider":"Equigerminal","version":"1.0","type":"link"}