{"product_id":"polyssaccharide-storage-myophaty-type-1-pssm1-qpcr","title":"PSSM1 Polysaccharide Storage Myopathy Type 1","description":"\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cmeta name=\"viewport\" content=\"width=device-width, initial-scale=1.0\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e\n        body {font-family: Arial, sans-serif; line-height: 1.6; background-color: #f9f9f9; color: #333; margin: 0; padding: 0;}\n        .content {padding: 20px;}\n        h2 {color: #E11BE9; margin-top: 20px;}\n        ul {list-style-type: square; padding-left: 20px;}\n        .toggle-btn {display: inline-block; margin-top: 10px; padding: 10px 20px; background-color: #119EC2; color: white; text-align: center; text-decoration: none; border-radius: 5px; cursor: pointer;}\n        .toggle-btn:hover {background-color: #0b7a96;}\n        .highlight {background-color: #f3e5f5; padding: 10px; border-left: 4px solid #E11BE9; margin-bottom: 20px;}\n        .expandable {display: none; margin-top: 20px;}\n    \u003c\/style\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"content\"\u003e\n\u003ch2\u003eAbout the Test\u003c\/h2\u003e\n\u003cp class=\"highlight\"\u003eThe PSSM1 DNA test verifies the presence of the affected allele at the GYS1 locus responsible for Polysaccharide Storage Myopathy Type 1 (PSSM1).\u003c\/p\u003e\n\u003ch2\u003eSample Collection\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHair Roots:\u003c\/strong\u003e 20 to 30 hair roots. Pull the hair and tape it onto the \u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/DNA_FormNewAddress.pdf?v=1724086853\"\u003eprintable sample submission form.\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlood Sample:\u003c\/strong\u003e 5 mL blood in a K3 EDTA tube. Collect the blood and send the tube together with the \u003ca rel=\"noopener\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/DNA_FormNewAddress.pdf?v=1724086853\" target=\"_blank\"\u003eprintable sample submission form.\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eTurnaround Time\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStandard Processing:\u003c\/strong\u003e Results in 5 working days after sample arrival at the laboratory. Clients organize and cover the costs of sending the samples.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhy Test?\u003c\/h2\u003e\n\u003cp\u003eThis genetic test helps breeders identify horses carrying the PSSM allele. Informed breeding choices can prevent the birth of affected foals. While PSSM cannot be cured, muscle function can be managed with dietary changes and exercise routines.\u003c\/p\u003e\n\u003cp\u003eThe PSSM1 test is required by many studbooks and is highly recommended when considering the purchase of a horse. Testing for PSSM1 as part of the pre-purchase examination can ensure that you are making an informed decision, as the condition can impact the horse's performance and overall health.\u003c\/p\u003e\n\u003ca class=\"toggle-btn\"\u003eLearn More\u003c\/a\u003e\n\u003cdiv class=\"expandable\" id=\"learn-more-content\"\u003e\n\u003ch2\u003eResults Description\u003c\/h2\u003e\n\u003cp\u003eThe DNA test results will be one of the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003en\/n:\u003c\/strong\u003e Negative for PSSM1. No affected allele present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003en\/P1:\u003c\/strong\u003e Positive heterozygous for PSSM1. One mutated allele present. The horse can pass the PSSM1 allele to 50% of its progeny.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eP1\/P1:\u003c\/strong\u003e Positive homozygous for PSSM1. Two mutated alleles present. The horse will pass the PSSM1 allele to 100% of its offspring.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eAdditional Information\u003c\/h2\u003e\n\u003cp\u003ePolysaccharide Storage Myopathy (PSSM1) is a hereditary muscle disease that affects many breeds. The condition is caused by a mutation in the GYS1 gene, leading to an abnormal accumulation of glycogen in the muscles. This can cause symptoms such as muscle tremors, stiffness, reluctance to move, and excessive sweating. Management of PSSM1 includes dietary changes and regular exercise to help mitigate symptoms.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ca class=\"toggle-btn\"\u003eCheck our FAQs for more information\u003c\/a\u003e\n\u003cdiv class=\"expandable\" id=\"faq-content\"\u003e\n\u003ch2\u003eFAQs\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat breeds are affected by PSSM1?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePSSM1 affects many breeds, including Quarter Horses, Belgian Draft Horses, and Warmbloods. The prevalence of the mutation varies by breed, with some breeds having a higher incidence of the condition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow is PSSM1 inherited?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePSSM1 is inherited in an autosomal dominant manner, meaning that horses with one (n\/P1) or two (P1\/P1) copies of the mutated gene can develop the disease. Horses with two copies generally show more severe symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow can PSSM1 be managed?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eManagement includes dietary modifications to reduce starch and sugar intake, and a consistent exercise regimen. These measures can help prevent the onset of symptoms or reduce their severity.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/equigerminal.shop\/pages\/faqs\" target=\"_blank\"\u003eVisit our full FAQ page\u003c\/a\u003e for more details.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Equigerminal","offers":[{"title":"Standard. Results in 5 days","offer_id":47813083988296,"sku":"","price":43.05,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/PSSM1test.png?v=1716890764","url":"https:\/\/www.equigerminal.org\/tr\/products\/polyssaccharide-storage-myophaty-type-1-pssm1-qpcr","provider":"Equigerminal","version":"1.0","type":"link"}