{"product_id":"special-offer-package-pssm1-wffs-30-off","title":"WFFS\/FFS \u0026 PSSM1 - DNA Test bundle","description":"\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cmeta content=\"width=device-width, initial-scale=1.0\" name=\"viewport\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e\n        body {font-family: Arial, sans-serif; line-height: 1.6; background-color: #f9f9f9; color: #333; margin: 0; padding: 0;}\n        .content {padding: 20px;}\n        h2 {color: #E11BE9; margin-top: 20px;}\n        h3 {color: #119EC2; margin-top: 20px;}\n        ul {list-style-type: square; padding-left: 20px;}\n        .toggle-btn {display: inline-block; margin-top: 10px; padding: 10px 20px; background-color: #119EC2; color: white; text-align: center; text-decoration: none; border-radius: 5px; cursor: pointer;}\n        .toggle-btn:hover {background-color: #0b7a96;}\n        .highlight {background-color: #f3e5f5; padding: 10px; border-left: 4px solid #E11BE9; margin-bottom: 20px;}\n        .expandable {display: none; margin-top: 20px;}\n        .shaded-box {background-color: #f9f9f9; border: 1px solid #ddd; padding: 15px; border-radius: 5px; box-shadow: 0 2px 4px rgba(0,0,0,0.1); margin-bottom: 20px;}\n        .section-title {color: #E11BE9; padding: 10px; margin-bottom: 10px; font-size: 1.2em;}\n    \u003c\/style\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"content\"\u003e\n\u003ch2\u003eDNA Test Bundle: PSSM1 \u0026amp; WFFS\u003c\/h2\u003e\n\u003cdiv class=\"highlight\"\u003e\n\u003cp\u003e\u003cstrong\u003eDiscover Peace of Mind with Precision Equine Genetics.\u003c\/strong\u003e Our DNA test bundle offers a comprehensive genetic screening for Polysaccharide Storage Myopathy Type 1 (PSSM1) and Warmblood Fragile Foal Syndrome (WFFS), empowering you with essential information for the wellbeing of your equine companion.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eTests Included\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePSSM1 Genetic Test:\u003c\/strong\u003e Uncover the presence of the specific allele at the GYS1 locus responsible for PSSM1, a condition affecting muscle metabolism in horses. Early detection can guide management and care. Learn more about the PSSM1 test \u003ca href=\"https:\/\/equigerminal.shop\/products\/polyssaccharide-storage-myophaty-type-1-pssm1-qpcr\" target=\"_blank\"\u003ehere\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWFFS Genetic Test:\u003c\/strong\u003e This test identifies the allele at the PLOD1 locus responsible for Warmblood Fragile Foal Syndrome (WFFS). Knowing your horse's genetic status aids in making informed breeding decisions. Further details on the WFFS test can be found \u003ca href=\"https:\/\/equigerminal.shop\/products\/warmblood-fragile-foal-syndrome-wffs-qpcr?_pos=2\u0026amp;_sid=1c7559dd5\u0026amp;_ss=r\" target=\"_blank\"\u003ehere\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSample Collection\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003e20-30 hair roots. Tape the hair to the\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/DNA_FormNewAddress.pdf?v=1724086853\"\u003e printable sample submission form.\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eAlternatively, 5 mL blood in an EDTA tube. Send the tube with the \u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/DNA_FormNewAddress.pdf?v=1724086853\" target=\"_blank\" rel=\"noopener\"\u003eprintable sample submission form.\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eTurnaround Time\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStandard Processing:\u003c\/strong\u003e Results in 5 working days after sample arrival at the laboratory. Clients organize and cover the costs of sending the samples.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePremium Processing:\u003c\/strong\u003e Results in 2 working days after sample arrival. \u003cmeta charset=\"UTF-8\"\u003e \u003cspan\u003eThis service includes free express delivery. For an additional fee of €35, the laboratory arranges express shipping with package pick-up from your address (available for non-remote regions). For premium processing, please contact the laboratory at \u003c\/span\u003e\u003ca rel=\"noreferrer\" target=\"_new\"\u003esupport@equigerminal.pt\u003c\/a\u003e\u003cspan\u003e for further assistance.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eWhy Test?\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cp\u003eThis genetic test helps breeders identify horses carrying the PSSM1 and WFFS alleles. Informed breeding choices can prevent the birth of affected foals. While PSSM1 affects muscle metabolism, WFFS is a fatal connective tissue disorder. Testing for these conditions is often required by studbooks and is highly recommended during pre-purchase exams to ensure the horse's health and performance.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ca class=\"toggle-btn\" onclick=\"toggleSection('learn-more-content')\"\u003eLearn More\u003c\/a\u003e\n\u003cdiv class=\"expandable\" id=\"learn-more-content\"\u003e\n\u003ch3 class=\"section-title\"\u003eResults Description\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe DNA test results will be one of the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePSSM1 n\/n:\u003c\/strong\u003e Negative for PSSM1. No affected allele present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePSSM1 n\/P1:\u003c\/strong\u003e Positive heterozygous for PSSM1. One mutated allele present. The horse can pass the PSSM1 allele to 50% of its progeny.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePSSM1 P1\/P1:\u003c\/strong\u003e Positive homozygous for PSSM1. Two mutated alleles present. The horse will pass the PSSM1 allele to 100% of its offspring.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWFFS n\/n:\u003c\/strong\u003e Negative for WFFS. No affected allele present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWFFS n\/WFFS:\u003c\/strong\u003e Carrier for WFFS. One copy of the mutated allele present. The horse can pass the WFFS allele to 50% of its progeny.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWFFS WFFS\/WFFS:\u003c\/strong\u003e Positive for WFFS. Two copies of the mutated allele present. The foal will exhibit severe clinical signs and must be euthanized shortly after birth due to the untreatable nature of the disease. Such foals will not survive to adulthood and hence will not pass on the allele.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"section-title\"\u003eAdditional Information\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003ePolysaccharide Storage Myopathy (PSSM1) is a hereditary muscle disease affecting many breeds, caused by a mutation in the GYS1 gene. Warmblood Fragile Foal Syndrome (WFFS) is a fatal genetic defect of connective tissue, resulting from a mutation in the PLOD1 gene. WFFS is characterized by hyperextensible, fragile skin and mucous membranes, leading to severe lesions and often resulting in euthanasia of affected foals shortly after birth. Both conditions can significantly impact a horse's health and performance, making genetic testing an essential tool for breeders and buyers.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"section-title\"\u003eReferences\u003c\/h3\u003e\nAblondi, M., et al. (2022). \u003ca href=\"https:\/\/doi.org\/10.1186\/s12711-021-00693-4\" target=\"_blank\"\u003ePerformance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects\u003c\/a\u003e. Genet Sel Evol 54, 4.Rowe, Á., et al. (2021). \u003ca href=\"https:\/\/doi.org\/10.1186\/s13620-021-00206-1\" target=\"_blank\"\u003eWarmblood fragile foal syndrome causative single nucleotide polymorphism frequency in horses in Ireland\u003c\/a\u003e. Ir Vet J 74, 27.Dias, N. M., et al. (2019). \u003ca\u003eDias, N. M., et al. (2019). \u003c\/a\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.tvjl.2019.05.002\" target=\"_blank\"\u003eWarmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil\u003c\/a\u003e. Vet J 248, 101–102.Hoelzle, L., et al. (2020). \u003ca href=\"https:\/\/doi.org\/10.3390\/genes11121518\" target=\"_blank\"\u003eDistribution of the Warmblood Fragile Foal Syndrome Type 1 Mutation (PLOD1 c.2032G\u0026gt;A) in Different Horse Breeds from Europe and the United States\u003c\/a\u003e. Genes 11(12), 1518.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003ca class=\"toggle-btn\" onclick=\"toggleSection('faq-content')\"\u003eCheck our FAQs for more information\u003c\/a\u003e\u003c\/p\u003e\n\u003cdiv class=\"expandable\" id=\"faq-content\"\u003e\n\u003ch3 class=\"section-title\"\u003eFAQs\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eWhat breeds are affected by PSSM1 and WFFS?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePSSM1 affects many breeds, including Quarter Horses, Belgian Draft Horses, and Warmbloods. WFFS primarily affects Warmbloods but has also been detected in breeds like Thoroughbreds, Knabstruppers, Haflingers, and American Sport Ponies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow are PSSM1 and WFFS inherited?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePSSM1 is inherited in an autosomal dominant manner, meaning horses with one (n\/P1) or two (P1\/P1) copies of the mutated gene can develop the disease. WFFS is inherited as an autosomal recessive trait, requiring two copies of the mutated gene (WFFS\/WFFS) for the disease to manifest. Affected foals with two copies of the WFFS mutation will not survive to adulthood and must be euthanized shortly after birth.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow can PSSM1 and WFFS be managed?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePSSM1 management includes dietary modifications to reduce starch and sugar intake, and a consistent exercise regimen. WFFS, however, is a lethal condition with no cure, emphasizing the importance of genetic testing to inform breeding decisions and avoid producing affected foals.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/equigerminal.shop\/pages\/faqs\" target=\"_blank\"\u003eVisit our full FAQ page\u003c\/a\u003e for more details.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":41990960906390,"sku":"","price":73.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/FFSPSSM1.png?v=1711469296","url":"https:\/\/www.equigerminal.org\/tr\/products\/special-offer-package-pssm1-wffs-30-off","provider":"Equigerminal","version":"1.0","type":"link"}