{"product_id":"hyperkalemic-periodic-paralysis-hypp","title":"HYPP Hyperkalemic Periodic Paralysis","description":"\u003cp\u003e\u003cspan style=\"font-size: 1.4em;\" class=\"s1\"\u003eDNA test for the Hyperkalemic Periodic Paralysis Disease (HYPP). \u003c\/span\u003e\u003cspan style=\"font-size: 1.4em;\" class=\"s1\"\u003eThis DNA test verifies the presence of the recessive HYPP gene.\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cspan style=\"color: #c739d2;\" color=\"#c739d2\"\u003eSample \u003cspan style=\"caret-color: #c739d2;\"\u003erequirements\u003c\/span\u003e \u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e30 to 40 hair roots \u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cspan\u003eor\u003c\/span\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e5 mL of blood in K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eTurnaround time\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e2 to 5  working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cimg style=\"float: none;\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/F_ISAG_MEMBER_small.jpg?v=1563820312\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #e8b80d;\"\u003e\u003cstrong\u003eWhy test?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan class=\"s1\"\u003eThis genetic test helps breeders to identify horses that carrying the HYPP recessive gene. Informed choices can be made for breeding selections, and prevent the born of affected foals. \u003c\/span\u003eAll offspring of Impressive should be tested for HYPP.\u003c\/li\u003e\n\u003cli\u003eBecause HYPP is dominant disorder, the effects of it can also be transposed to other breeds of horses when intermixing occurs. This test is important in preserving the inherited health of all horses.\u003c\/li\u003e\n\u003cli\u003eHorses with suspicious symptoms of the disease should also be tested.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #00afab;\"\u003e\u003cstrong\u003eResults description\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003cspan class=\"s1\"\u003eThe DNA test verifies the presence of the recessive HYPP gene and presents results as one of the following:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eN\/\u003c\/b\u003e –  \u003cstrong\u003eNormal - \u003c\/strong\u003eAbsence of the allele responsible for HYPP.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eN\/H\u003c\/strong\u003e – \u003cstrong\u003eAffected - Positive heterozygous for HYPP.\u003c\/strong\u003e Presence of one copy of the allele responsible for HYPP. The horse is affected with the HYPP disorder and there is a 50% chance this horse will pass a HYPP allele to its offspring.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eH\/\u003c\/strong\u003e \u003cstrong\u003e– Affected- Positive homozygous for HYPP\u003c\/strong\u003e. Presence of two copies of the allele responsible for HYPP. The horse is affected with the HYPP disorder and there is a 100% chance this horse will pass a HYPP allele to its offspring.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHyperkalemic Periodic paralysis (HYPP) is an inherited disease of the muscle, which is caused by an inherited genetic mutation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eA point mutation in DNA exists in the sodium channel gene, which codes for an abnormal channel to be expressed in skeletal muscle. This mutation is passed on to offspring.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSodium channels are “pores” in the muscle cell membrane which control contraction of the muscle fibers. When the defective sodium channel gene is present, the channel becomes “leaky” and makes the muscle overly excitable and contract involuntarily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThe channel become “leaky” when potassium levels fluctuate in the blood. This may occur with fasting followed by consumption of a high potassium feed such as alfalfa. Hyperkalemia, which is an excessive amount of potassium in the blood, causes the muscles in the horse to contract more readily than normal. This makes the horse susceptible to sporadic episodes of muscle tremors or paralysis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSeverity of attacks varies from unnoticeable to collapse or sudden death. The cause of death is usually respiratory failure and\/or cardiac arrest.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThis genetic defect has been identified in offspring of the American Quarter Horse sire, Impressive. To date, confirmed cases of HYPP have been restricted to descendants of this horse. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHYPP is a dominant disorder meaning both homozygous positive (HH) and heterozygous (nH) horses will be affected. Only homozygous negative (nn) horses are not affected by HYPP.\u003c\/span\u003e\u003c\/p\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":29451379081260,"sku":"","price":43.05,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/products\/HYPP.png?v=1571094950","url":"https:\/\/www.equigerminal.org\/zh\/products\/hyperkalemic-periodic-paralysis-hypp","provider":"Equigerminal","version":"1.0","type":"link"}