{"product_id":"silver-dilution","title":"Silver dilution (Dapple)","description":"\u003cdiv\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eDNA test\u003c\/strong\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan class=\"s1\"\u003eThe genetic test verifies the presence of the\u003cstrong\u003e Silver\u003c\/strong\u003e \u003cspan\u003ecoat dilution modifier.\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan class=\"s1\"\u003eThe Silver\u003c\/span\u003e genetic variant is associated with \u003cstrong\u003eMultiple Congenital Ocular Abnormalities\u003c\/strong\u003e (MCOA) in some breeds.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cspan style=\"font-size: 1.4em;\"\u003e \u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eSample\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e30 to 40 - hair roots - envelope\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cspan\u003eor\u003c\/span\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e5 mL - blood - K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #c739d2;\"\u003e\u003cstrong\u003eTurnaround time\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e2 to 5  working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cimg alt=\"\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/F_ISAG_MEMBER_small.jpg?v=1563820312\" style=\"float: none;\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #00afab;\"\u003e\u003cstrong\u003eResults description\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThe DNA test verifies the presence of the silver gene and presents results as one of the following:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan class=\"s1\"\u003eN\/ \u003c\/span\u003e\u003c\/strong\u003e– \u003cstrong\u003eNegative for Silver\u003c\/strong\u003e - No evidence of the genetic variant for Silver. No risk to develop \u003cspan\u003e Multiple Congenital Ocular Abnormalities (MCOA) associated to Silver.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eZ\/N\u003c\/strong\u003e - \u003cstrong\u003eHeterozygous for Silver\u003c\/strong\u003e - The Black and Bay basic coat colour will be diluted by Silver. Black-based horses will be chocolate with flaxen mane and tail. Bay-based horses will have pigment on lower legs lightened and flaxen mane and tail. No effect on chestnut color. Moderate risk to develop MCOA.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eZ\/\u003c\/strong\u003e – \u003cstrong\u003eHomozygous for Silver\u003c\/strong\u003e - Two copies of altered sequence detected. Black-based horses will be chocolate with flaxen mane and tail. Bay-based horses will have pigment on lower legs lightened and flaxen mane and tail. No effect on chestnut color, but will pass the variant on to 100% of offspring.  Higher\u003cspan\u003e risk to develop severe MCOA.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003c\/span\u003eThe Silver dilution behaves as a coat colour \u003cspan\u003edominant trait on bay and black base coat colours. W\u003c\/span\u003e\u003cspan\u003ehile\u003c\/span\u003e chestnut base colour is not affected by the Silver dilution and can pass the variant silently to the offspring. \u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eIn short, the Silver dilution variant (Z) will only affect coat colour phenotype of black pigmented horses (E\/e or E\/E) and has no effect on red pigmented horses (e\/e). \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan\u003eIn addition, the eye disorders associated to Silver genetic variant are incomplete autosomal dominant:  homozygous horses (with two copies of Z)  may be at higher risk of developing severe Multiple Congenital Ocular Abnormalities (MCOA), while heterozygous (with one copy of Z) may develop a milder form of MCOA.  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003c\/span\u003e\u003cspan class=\"s1\"\u003eThe effects of the silver dilution on coat colour gene can vary widely.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eThe agouti gene affects the coat colour by controlling the distribution of the black pigment whereas the\u003cspan style=\"text-decoration: underline;\"\u003e Silver dilution\u003c\/span\u003e variant dilutes areas of the black pigment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003c\/span\u003e\u003cspan class=\"s1\"\u003eDilution by the Silver variant on a horse with a uniform \u003cspan style=\"text-decoration: underline;\"\u003eblack base\u003c\/span\u003e typically involves lightening of the mane and tail and a dilution of the body to a chocolate color, often \u003cspan style=\"text-decoration: underline;\"\u003edappled\u003c\/span\u003e as well.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eA \u003cspan style=\"text-decoration: underline;\"\u003eBay horse\u003c\/span\u003e carrying the Silver gene will usually have a lightened mane and tail, as well as lightened lower legs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eIt is important to know that although a red horse (e\/e) will not be diluted by the silver variant, it can be a carrier of the genetic variant and thus potentially pass the gene on to its offspring.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSilver dilution has been identified in a number of horse breeds including the Quarter horse, the Rocky Mountain horse, the Icelandic horse, Morgans, Shetland ponies and the Miniature horse.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cstrong\u003e\u003cspan class=\"s1\"\u003eReferences:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBrunberg, E., Andersson, L., Cothran, G., Sandberg, K., Mikko, S., Lindgren, G.: A missense mutation in PMEL17 is associated with the silver \u003cmark class=\"hilite term-0\"\u003e\u003c\/mark\u003ecoat color in the horse. BMC Genetics 7:46, 2006.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAndersson, L.S., Wilbe, M., Viluma, A., Cothran, G., Ekesten, B., Ewart, S., Lindgren, G.: Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMEL. PLoS One 8:e75639, 2013.\u003c\/span\u003e\u003c\/p\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":29451076272172,"sku":"","price":43.05,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/products\/Silver.png?v=1571095115","url":"https:\/\/www.equigerminal.org\/zh\/products\/silver-dilution","provider":"Equigerminal","version":"1.0","type":"link"}