{"product_id":"warmblood-fragile-foal-syndrome-wffs-qpcr","title":"FFS (WFFS) Fragile Foal Syndrome","description":"\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cmeta name=\"viewport\" content=\"width=device-width, initial-scale=1.0\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e\n        body {font-family: Arial, sans-serif; line-height: 1.6; background-color: #f9f9f9; color: #333; margin: 0; padding: 0;}\n        .content {padding: 20px;}\n        h2 {color: #E11BE9; margin-top: 20px;}\n        h3 {color: #119EC2; margin-top: 20px;}\n        ul {list-style-type: square; padding-left: 20px;}\n        .toggle-btn {display: inline-block; margin-top: 10px; padding: 10px 20px; background-color: #119EC2; color: white; text-align: center; text-decoration: none; border-radius: 5px; cursor: pointer;}\n        .toggle-btn:hover {background-color: #0b7a96;}\n        .highlight {background-color: #f3e5f5; padding: 10px; border-left: 4px solid #E11BE9; margin-bottom: 20px;}\n        .expandable {display: none; margin-top: 20px;}\n        .shaded-box {background-color: #f9f9f9; border: 1px solid #ddd; padding: 15px; border-radius: 5px; box-shadow: 0 2px 4px rgba(0,0,0,0.1); margin-bottom: 20px;}\n        .section-title {color: #E11BE9; padding: 10px; margin-bottom: 10px; font-size: 1.2em;}\n    \u003c\/style\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"content\"\u003e\n\u003ch2\u003eWFFS DNA Test\u003c\/h2\u003e\n\u003cdiv class=\"highlight\"\u003e\n\u003cp\u003e\u003cstrong\u003eEnsure the Health and Future of Your Horses with Accurate WFFS Testing.\u003c\/strong\u003e Our DNA test verifies the presence of the affected allele at the PLOD1 locus responsible for Warmblood Fragile Foal Syndrome (WFFS), also known as Fragile Foal Syndrome (FFS).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSample Requirements\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003e30 to 40 hair roots - envelope\u003c\/li\u003e\n\u003cli\u003eAlternatively, 5 mL blood - K3 EDTA tube\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eTurnaround Time\u003c\/h3\u003e\n\u003cdiv class=\"shaded-box\"\u003e\n\u003cul\u003e\n\u003cli\u003e2 to 5 working days\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eResults Description\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe DNA test verifies the presence of the affected allele at the PLOD1 locus responsible for WFFS and presents results as one of the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003en\/n:\u003c\/strong\u003e Negative for WFFS. No affected allele present. The horse is not a carrier of the WFFS mutation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003en\/WFFS:\u003c\/strong\u003e Carrier, heterozygous for WFFS. One mutated allele present. The horse can pass the WFFS allele to 50% of its progeny when bred.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWFFS\/WFFS:\u003c\/strong\u003e Positive, homozygous for WFFS. Two mutated alleles present. The foal will exhibit severe clinical signs and must be euthanized shortly after birth due to the untreatable nature of the disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003eGenetic Inheritance\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eWarmblood Fragile Foal Syndrome (WFFS) is an inherited autosomal recessive disorder caused by a single mutation in the PLOD1 gene.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eClinical Signs and Affected Breeds\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe disease is present at birth. Affected foals have skin that lacks tensile strength, characterized by tearing, ulceration, and other lesions from normal contact. Lesions are most noted on pressure points, gums, and other oral cavity mucous membranes. Limb joints are lax and hyper-extensible, making it difficult for affected foals to stand normally.\u003c\/p\u003e\n\u003cp\u003eWFFS\/FFS is similar to Ehlers Danlos Syndrome (EDS) in humans. The mutation has been reported in Warmblood breeds (11-30% carriers) and at low frequency in Thoroughbreds (2.75% of Irish Thoroughbreds), as well as in Hanoverian, Selle Français, KWPN, Oldenburg, and Westphalians.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eWhy Test?\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eTesting for WFFS is crucial for breeders to make informed decisions. By identifying carriers and avoiding breeding two carriers together, the risk of producing affected foals can be minimized. This helps ensure the health and wellbeing of future generations of horses.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ca class=\"toggle-btn\" onclick=\"toggleSection('learn-more-content')\"\u003eLearn More\u003c\/a\u003e\n\u003cdiv class=\"expandable\" id=\"learn-more-content\"\u003e\n\u003ch3 class=\"section-title\"\u003eDetailed Results Description\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe DNA test results will be one of the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003en\/n:\u003c\/strong\u003e Negative for WFFS. No affected allele present. The horse is not a carrier of the WFFS mutation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003en\/WFFS:\u003c\/strong\u003e Carrier, heterozygous for WFFS. One mutated allele present. The horse can pass the WFFS allele to 50% of its progeny when bred.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWFFS\/WFFS:\u003c\/strong\u003e Positive, homozygous for WFFS. Two mutated alleles present. The foal will exhibit severe clinical signs and must be euthanized shortly after birth due to the untreatable nature of the disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"section-title\"\u003eAdditional Information\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eWarmblood Fragile Foal Syndrome (WFFS) is a fatal genetic defect of connective tissue, resulting from a mutation in the PLOD1 gene. WFFS is characterized by hyperextensible, fragile skin and mucous membranes, leading to severe lesions and often resulting in euthanasia of affected foals shortly after birth. This condition significantly impacts a horse's health and performance, making genetic testing an essential tool for breeders and buyers.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"section-title\"\u003eReferences\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAblondi, M., et al. (2022). \u003ca href=\"https:\/\/doi.org\/10.1186\/s12711-021-00693-4\" target=\"_blank\"\u003ePerformance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects\u003c\/a\u003e. Genet Sel Evol 54, 4.\u003c\/li\u003e\n\u003cli\u003eRowe, Á., et al. (2021). \u003ca href=\"https:\/\/doi.org\/10.1186\/s13620-021-00206-1\" target=\"_blank\"\u003eWarmblood fragile foal syndrome causative single nucleotide polymorphism frequency in horses in Ireland\u003c\/a\u003e. Ir Vet J 74, 27.\u003c\/li\u003e\n\u003cli\u003eDias, N. M., et al. (2019). \u003ca href=\"https:\/\/doi.org\/10.1016\/j.tvjl.2019.05.002\" target=\"_blank\"\u003eWarmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil\u003c\/a\u003e. Vet J 248, 101–102.\u003c\/li\u003e\n\u003cli\u003eHoelzle, L., et al. (2020). \u003ca href=\"https:\/\/doi.org\/10.3390\/genes11121518\" target=\"_blank\"\u003eDistribution of the Warmblood Fragile Foal Syndrome Type 1 Mutation (PLOD1 c.2032G\u0026gt;A) in Different Horse Breeds from Europe and the United States\u003c\/a\u003e. Genes 11(12), 1518.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ca class=\"toggle-btn\" onclick=\"toggleSection('faq-content')\"\u003eCheck our FAQs for more information\u003c\/a\u003e\n\u003cdiv class=\"expandable\" id=\"faq-content\"\u003e\n\u003ch3 class=\"section-title\"\u003eFAQs\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eWhat breeds are affected by WFFS?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWFFS primarily affects Warmbloods but has also been detected in breeds like Thoroughbreds, Knabstruppers, Haflingers, and American Sport Ponies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow is WFFS inherited?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWFFS is inherited as an autosomal recessive trait, requiring two copies of the mutated gene (WFFS\/WFFS) for the disease to manifest. Affected foals with two copies of the WFFS mutation will not survive to adulthood and must be euthanized shortly after birth.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow can WFFS be managed?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUnfortunately, there is no cure for WFFS. The condition is lethal, and affected foals exhibit severe clinical signs shortly after birth. The best management strategy is through genetic testing to inform breeding decisions and avoid producing affected foals.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is it important to test for WFFS?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTesting for WFFS is crucial for breeders to make informed decisions. By identifying carriers and avoiding breeding two carriers together, the risk of producing affected foals can be minimized. This helps ensure the health and wellbeing of future generations of horses.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/equigerminal.shop\/pages\/faqs\" target=\"_blank\"\u003eVisit our full FAQ page\u003c\/a\u003e for more details.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cscript\u003e\n        function toggleSection(id) {\n            var content = document.getElementById(id);\n            if (content.style.display === \"none\" || content.style.display === \"\") {\n                content.style.display = \"block\";\n            } else {\n                content.style.display = \"none\";\n            }\n        }\n    \u003c\/script\u003e\n\u003c\/div\u003e","brand":"Equigerminal","offers":[{"title":"Default Title","offer_id":29435119468588,"sku":"","price":43.05,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2726\/7968\/files\/FFStest.png?v=1716900031","url":"https:\/\/www.equigerminal.org\/zh\/products\/warmblood-fragile-foal-syndrome-wffs-qpcr","provider":"Equigerminal","version":"1.0","type":"link"}