MIM (PSSM2) DNA Test Ensure the Health and Performance of Your Horses with Accurate MIM Testing. Our DNA test identifies the presence of genetic variants associated with Muscle Integrity Myopathy (MIM), formerly known as PSSM2, which affects muscle function and structure. Sample Requirements 30 to 40 hair roots - envelope Alternatively, 5 mL blood - K3 EDTA tube Turnaround Time up to 15 working days Results Description The DNA test identifies six genetic variants that predispose horses to developing symptoms of Muscle Integrity Myopathy: P2: Myotilinopathy P3: Filaminopathy P4: Myozenin-3-Myopathy P8: PYROXD1-Myopathy Px: CACNA2D3-Myopathy K1: COL6A3-Myopathy Genetic Inheritance Muscle Integrity Myopathy (MIM) is caused by a hereditary predisposition involving multiple genetic variants. These variants disrupt the structure and function of muscle fibers, leading to symptoms such as muscle stiffness, unexplained lameness, and difficulty building muscle. Clinical Signs and Affected Breeds Symptoms of MIM can vary widely among horses and include unexplained lameness, muscle stiffness, difficulty with gait changes, reluctance to move, muscle atrophy, and behavioral changes. Almost any breed can be affected, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds. Why Test? Testing for MIM is crucial for breeders and owners to make informed decisions. By identifying carriers of the genetic variants, breeding choices can be optimized to prevent the spread of these disorders. Additionally, knowing a horse's genetic status can help manage and mitigate symptoms through tailored exercise and feeding protocols. Learn More Detailed Results Description The DNA test results will indicate the presence of the following genetic variants: P2: Myotilinopathy P3: Filaminopathy P4: Myozenin-3-Myopathy P8: PYROXD1-Myopathy Px: CACNA2D3-Myopathy K1: COL6A3-Myopathy Additional Information Muscle Integrity Myopathy (MIM) is a genetic disorder that disrupts muscle function and structure, leading to various clinical signs. While it is not possible to cure genetic disorders, optimized management through diet and exercise can help mitigate symptoms, allowing horses to lead normal lives. References Generatio. Muscle Integrity Myopathy in HorsesEquiSeq. Polysaccharide Storage Myopathy type 2 (PSSM2) Check our FAQs for more information FAQs What breeds are affected by MIM? Almost any breed can be affected by MIM, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds. How is MIM inherited? MIM is caused by multiple genetic variants that disrupt muscle structure and function. These variants are inherited and can predispose horses to developing symptoms of exertional myopathy. How can MIM be managed? While genetic disorders cannot be cured, their symptoms can often be managed through optimized feeding and exercise protocols. Identifying genetic variants through testing allows for tailored management strategies to mitigate symptoms. Visit our full FAQ page for more details.

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About the EquiSample Express Kit Tailored to Specific Test: The EquiSample Express Kit is customized based on the test purchased from Equigerminal. Complete Kit: Includes all necessary materials and prepaid express return shipping. Versatile Use: Suitable for both home tests and veterinary tests. Sample Collection: Collect samples yourself or consult a vet if a prescription is needed. Standardized Results: Ensures consistency without hassle, freeing up your vet to focus on care. Ideal for International Shipments: Perfect for tests requiring rapid sample delivery, like hormone assays, where sample stabilizers can't be used. How It Works 🛒 Purchase the Test and Kit: Select and buy the test and kit online. 📦 Receive the Kit: You will receive the kit at home with all necessary materials and prepaid express return shipping. 📄 Download the Submission Form: If you choose not to purchase the EquiSample Kit, download the submission form here. 📮 Return the Sample: Place the collected sample in the prepaid express envelope and use the door pickup service. If you did not purchase the kit, you are responsible for shipping the sample to our lab via regular mail. 📄 Receive Results: Get the result certificate by email. If you need assistance, contact us at support@equigerminal.pt. Types of Tests Home Tests: For healthy animals, these tests do not require invasive samples or veterinary prescriptions. Examples include: Genetic Tests: Saliva/swabs, mane root samples, and other non-invasive samples Parasitic Tests: Stool samples Nutritional Tests: Non-invasive samples Food Tests: Analysis of various food samples Veterinary Tests: For infectious diseases or sick animals, these tests require invasive sample collection (e.g., blood) and must be prescribed by a veterinarian. Veterinarians can also request specific kits and materials. Home Test Kits Include Genetic Tests: Includes a sealed card or envelope for mane samples, saliva/swabs, gloves, a sealed bag, and submission forms. Parasitic Tests: Includes tools for stool sample collection. Nutritional and Food Tests: Includes the necessary materials for collecting non-invasive samples and submission forms. Veterinary Test Kits Include For infectious disease tests, includes materials for invasive sample collection (e.g., blood) and submission forms. Veterinary-specific materials as requested. Pricing and Delivery Time Portugal & Spain : Delivery in 1 business day International: Delivery in 1-2 business days (Valid only for Europe in non-remote areas. For other regions, please contact us.) Multiple Animal Testing You can purchase kits for testing a single animal or multiple animals. The cost of transportation is unitary, meaning you only pay for shipping once, regardless of the number of animals being tested. FAQs View FAQs What is included in the EquiSample Kit? Each kit includes specific materials based on the type of test purchased, such as swabs, sealed tubes, gloves, submission forms, and a prepaid return envelope. How do I collect a sample? Detailed instructions for sample collection are provided with each kit. For home tests, follow the instructions carefully. For veterinary tests, your veterinarian will handle the sample collection. Can I purchase additional collection kits? Yes, you can purchase additional EquiSample Kits with all necessary materials and prepaid return shipping for a hassle-free experience. How do I return the sample? If you purchase the EquiSample Kit, place the collected sample in the provided prepaid envelope and drop it off at your national postal service (for Standard Kit) or use the door pickup service (for Express Kit). If you do not purchase the kit, you are responsible for shipping the sample to our lab via regular mail. How long does it take to receive the results? The turnaround time for most tests is typically 2 to 5 working days from the receipt of the sample in our laboratory. Who can I contact for support? If you need assistance, contact our support team at support@equigerminal.pt. Additional Information View More Info For more detailed information on the EquiSample Kits, including sample collection and submission instructions, please visit our website or contact our support team at support@equigerminal.pt. Visit our website for more details.

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Pathogen test  This test determines the NEV viral load of your horse by a molecular test that identifies the NEV genome in circulating blood. This test doesn’t determine the NEV status of your horse. An  undetectable viral load doesn't mean that your horse is free of infection.  Sample 5 mL - blood - K3 EDTA tube or 5 mL - Liquor (CSF). Turnaround time 5 to 10 working days Knowing the NEV status and viral load of your horse can help keep your horse - and others - safe Key points The New Equine Virus (NEV) is a horse lentivirus distinctive from Swamp fever virus (EIAV) and similar to HIV-1. Like in HIV infected humans NEV attacks the immune system and natural defence against illness.  A horse infected with NEV will get weaker and weaker until it can no longer fight off life threatening infections and diseases. The rate at which NEV progresses varies depending on age, general health and genetic background.    Learn more about NEV Explore results If NEV viral load is undetectable - No risk of transmitting NEV An undetectable viral load means that the NEV level in the blood is too low to be detected by a viral load test. NEV positive horses can show undetectable viral loads. Horses with NEV who maintain and undetectable viral load have effectively no risk of transmitting NEV to NEV  negative horses.  If NEV viral load is detectable - Risk of transmitting NEV A detectable viral load means that the NEV level in the blood is high to be detected by a viral load test. Horses with NEV who maintain and detectable viral load have effectively a risk of transmitting NEV to NEV  negative horses.    Take Action - Find the suggested next steps based on results. If your horse has a NEV detectable viral load begin by talking to your veterinarian about therapies to boost the immune system of your horse as well about antiretroviral therapy (ART). Monitoring of NEV viral load levels is crucial to evaluate disease progression and risk.  Like with HIV, ART can’t cure NEV, but can help your horse to live a longer and healthier life. The main goal of ART is to reduce your horse’s viral load to an undetectable level. Learn more about ART here

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Pathogen test   This diagnostic profile determines the NEV status of a horse, as well the transmitting with a viral load test.  Includes a serological test for NEV - to determine NEV status and a molecular test to determine the NEV viral load.  Sample 5 mL - blood - serum tube and 5 mL - blood - K3 EDTA tube or 5 mL - Liquor (CSF). Turnaround time 5 to 10 working days   Knowing the NEV status and viral load of your horse can help keep your horse - and others - safe Key points The New Equine Virus (NEV) is a horse lentivirus distinctive from Swamp fever virus (EIAV) and similar to HIV-1. Like in HIV infected humans NEV attacks the immune system and natural defence against illness.  A horse infected with NEV will get weaker and weaker until it can no longer fight off life threatening infections and diseases. The rate at which NEV progresses varies depending on age, general health and genetic background.  Learn more about NEV  Explore results If your horse is NEV negative : Testing shows that your horse doesn’t have NEV. Continue taking steps to keep your horse safe from getting NEV  If your horse is NEV positive : Testing shows that your horse does have NEV, but you can still take steps to protect your horse´s health. NEV viral load test indicates the transmitting risk. An undetectable viral load means that the NEV level in the blood is too low to be detected by a viral load test. Horses with NEV who maintain and undetectable viral load have effectively no risk of transmitting NEV to NEV  negative horses.  Learn more about NEV viral load Take action - Find the suggested next steps based on results If your horse is NEV positive Begin by talking to your veterinarian about therapies to boost the immune system of your horse as well about antiretroviral therapy (ART). Monitoring of NEV viral load levels is crucial to evaluate disease progression and risk.  Like with HIV, ART can’t cure NEV, but can help your horse to live a longer and healthier life. The main goal of ART is to reduce your horse’s viral load to an undetectable level. Learn more about ART here.

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