Produktformular

Melanom

Name: Melanom
Brand: Equigerminal
Price: 563.0 DKK

2 DNA-tests, der kan hjælpe med at forudsige den mulige type forekomst for udvikling af dermale melanomer på grå heste....

563,00 kr Inkl. moms

Om testen

Denne genetiske profil kombinerer DNA-test for grå (G)og Agouti (A)for at vurdere den genetiske risiko for at udvikle hudmelanomerhos skimmelsvagt heste.

Ved at bestemme, om en hest er heterozygot (G/N)eller homozygot (G/G)for gen for skimmel og identificere dens Agouti-genotype, giver denne test værdifuld information om risiko for melanom og understøtter informerede beslutninger vedrørende avl og sundhedsstyring.

Hvorfor teste?

Denne DNA-profil hjælper med at:

Vurdere den genetiske risiko for hudmelanom hos skimmelsvamp.
Bestemme grå (G) og Agouti (A) genotyper.
Understøtte avlsbeslutninger og langsigtet sundhedsovervågning.
Identificere heste med øget risiko for at udvikle melanomer.

Kliniske tegn

Melanomas in grey horses show as firm black lumps in the skin. They are most often found under the tail, around the anus and genitals, and on the lips and eyelids.

Studies report them in 50 to 80% of grey horses aged 15 or older
Most grow slowly and stay benign, but some spread

Transmission

The two genes are inherited separately. Each foal gets one copy of each gene from each parent, by chance. Neither gene is on a sex chromosome, so colts and fillies are the same.

Grey is dominant. One copy makes a horse grey. A G/N parent passes Grey to about half of its foals, a G/G parent to all of them. Two G/N parents give a G/G foal about one time in four.

The a version of Agouti, which gives a black base coat, is recessive. A foal is a/a only if both parents pass a. Two A/a parents give an a/a foal about one time in four. An A/A parent never produces an a/a foal.

Forebyggelse

There are two parts: breeding choices, and watching grey horses closely.

Breeding choices.

To avoid foals with two Grey copies, mate a grey horse to a non-grey partner
To avoid foals with two copies of the a version, use at least one parent that carries no a
To avoid grey-linked melanoma altogether, use two non-grey parents: no foal will be grey

Watching grey horses. Ask your veterinarian to check the skin at routine visits, and report any new lump. Treatment decisions belong to your veterinarian.

Resultater

Den genetiske profiltest verificerer genotypen af Grey og Agouti generne og præsenterer resultater som et af følgende:

Risiko for melanom

G/N+ A/aeller A/A– Moderat risikofor dermale melanomer.
G/N+ a/a– Moderat til høj risikofor dermale melanomer.
G/G+ A/aeller A/A– Høj risikofor dermale melanomer.
G/G+ a/a– Meget høj risikofor dermale melanomer.

Krav til prøver

5 ml - blod - K3 EDTA-rør

Behandlingstid

2 til 5 arbejdsdage

Sådan fungerer det

🛒 Koop de test: kies de test en koop hem online.

📧 Ontvang de instructies: na bevestiging van de betaling ontvangt u de instructies voor het afnemen van het monster per e-mail.

📄 Vul het formulier in: print het inzendformulier en vul het in met de identificatie van het dier.

✨ Neem het monster af: trek 20 tot 40 haren met wortel (bulbus) uit en plak ze in het gemarkeerde vak op het formulier, of laat uw dierenarts bloed afnemen in een K3-EDTA-buis.

📮 Stuur het naar het laboratorium: Equigerminal, S.A., HIESE, Rua da Quinta do Sobreiro, 25, Quinta Vale do Espinhal, 3230-343 Penela, PORTUGAL.

📊 Ontvang het rapport: het gecertificeerde rapport wordt uitgegeven zodra de analyse is gevalideerd.

Ofte stillede spørgsmål

Hvilken prøve er påkrævet?

Testen kræver 5 ml blod opsamlet i et K3 EDTA-rør.

Hvilke gener analyseres?

Testen evaluerer Grey (G)og Agouti (A)generne for at estimere den genetiske risiko for dermal melanom.

Betyder et højrisikoresultat, at min hest med sikkerhed vil udvikle melanom?

Nej. Testen estimerer genetisk disposition, ikke sikkerhed. Miljøfaktorer, alder og individuel variation påvirker også, om melanomer udvikles.

Hvilke heste bør testes?

Denne test anbefales til skimmelsvampe, især dem, der er beregnet til avl, eller dem, der kræver langsigtet sundhedsovervågning.

Hvor lang tid tager det at modtage resultaterne?

Resultater er tilgængelige inden for 2 til 5 arbejdsdageefter prøvens ankomst til laboratoriet.

For Professionals

Genetic and clinical detail for veterinarians, geneticists and laboratories.

Gene / locus: two loci. STX17 (syntaxin 17), Grey, ECA25; ASIP (agouti signalling protein), Agouti, ECA22.
Variant: Grey: 4.6 kb intronic copy-number variant, NC_009168.3:g.6625295_6629872dup (G2) or g.6625295_6629872[3] (G3). Agouti a: NC_009165.3:g.26067463_26067473del; NM_001164017.1:c.187_197del.
Alternative designations: Grey was published as a 4.6 kb duplication (Rosengren Pielberg et al., 2008) and later resolved into G2 and G3 copy-number alleles (Rubin et al., 2024). Agouti a was published as c.191_201del (Rieder et al., 2001).
Variant identifiers: Grey: OMIA variants 438 (G2) and 1732 (G3), no rs/EVA identifier. Agouti a: rs3091770233; OMIA variant 509.
Variant classification: not currently evaluated (ISAG/AVCG, per OMIA) for all three variants.
Inheritance: Grey autosomal dominant (OMIA code D); Agouti a autosomal recessive for black.
Penetrance / expressivity: in 694 grey Lipizzaners, G/G horses had more severe melanoma than G/N; among horses older than 6 years, melanoma was more severe in a/a than A/A, with A/a intermediate; ASIP did not affect greying (Rosengren Pielberg et al., 2008). In 335 grey Quarter Horses, melanoma was about twice as common in G/G as in G/N, with no ASIP effect detected; prevalence 16% at all ages, 52% over 15 years and 10% under 15 years (Teixeira et al., 2013). G3 carries the high melanoma risk; none of 25 G2 Connemara ponies aged 15 to 35 had melanoma (Rubin et al., 2024).
Breeds: Grey is reported in Lipizzaners, Arabians, Connemara ponies, Thoroughbreds, Welsh ponies, Icelandic horses, New Forest ponies, Shetland ponies and Quarter Horses, and in at least 62 breeds and populations overall. Agouti occurs in all breeds.
Clinical notes for veterinarians: the risk ranking rests mainly on the Lipizzaner cohort (Rosengren Pielberg et al., 2008).

Key references:

Rosengren Pielberg G, Golovko A, Sundstrom E, et al. (2008). A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet 40:1004-1009. doi:10.1038/ng.185. PMID 18641652.
Teixeira RBC, Rendahl AK, Anderson SM, et al. (2013). Coat color genotypes and risk and severity of melanoma in gray Quarter Horses. J Vet Intern Med 27:1201-1208. doi:10.1111/jvim.12133.
Rubin CJ, Hodge M, Naboulsi R, et al. (2024). An intronic copy number variation in Syntaxin 17 determines speed of greying and melanoma incidence in Grey horses. Nat Commun 15:7510. doi:10.1038/s41467-024-51898-2. PMID 39209879.
Rieder S, Taourit S, Mariat D, Langlois B, Guerin G (2001). Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses. Mamm Genome 12:450-455. doi:10.1007/s003350020017. PMID 11353392.