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Zertifiziert als DNA-störungsfrei

Name: Zertifiziert als DNA-störungsfrei
Brand: Equigerminal
Price: 299.0 EUR

Stellen Sie mit unserem umfassenden DNA-Testpanel sicher, dass die Abstammung Ihres Pferdes frei von genetischen Störungen ist. Zertifizieren Sie Ihr...

€299.00 Inkl. MwSt

Über den Test

Stellen Sie mit unserem umfassenden DNA-Testpanel sicher, dass die Abstammung Ihres Pferdes frei von genetischen Störungen ist. Zertifizieren Sie Ihr Pferd gegen 10 genetische Störungen: SCID, LFS, CA, PSSM1, HYPP, GBED, HERDA, MH, CM, WFFS.

Warum testen?

Unser Test für zertifizierte DNA-krankheitsfreie Linien hilft Züchtern, Käufern und Zuchtbuchzertifizierern sicherzustellen, dass Pferde frei von genetischen Störungen sind. Dies gewährleistet gesündere Pferde, fundierte Zuchtentscheidungen und ein besseres Gefühl der Sicherheit.

Klinische Zeichen

What each disease looks like in an affected horse:

SCID (Severe Combined Immunodeficiency): the foal looks normal at birth, then from about 10 days old has repeated infections and dies in the first months
LFS (Lavender Foal Syndrome): a pale-coated newborn foal with fits, unable to stand or nurse
CA (Cerebellar Abiotrophy): head tremor and poor balance, usually starting between about six weeks and four months of age
PSSM1 (Type 1 Polysaccharide Storage Myopathy): stiffness, reluctance to go forward and tying-up after exercise
HYPP (Hyperkalemic Periodic Paralysis): attacks of muscle tremor and weakness that come and go
GBED (Glycogen Branching Enzyme Deficiency): abortion, stillbirth, or a weak foal that dies within weeks
HERDA (Hereditary Equine Regional Dermal Asthenia): fragile skin that tears and scars, often first noticed when the horse is started under saddle
MH (Malignant Hyperthermia): a normal-looking horse that has a fast, potentially fatal attack during anaesthesia, hard exercise or stress
CM (Congenital Myotonia): muscles that are slow to relax, so the pony is stiff and struggles to get up
WFFS (Warmblood Fragile Foal Syndrome): abortion, stillbirth, or a foal born too weak and fragile to survive

None of these signs is unique to one disease. In a sick horse, your veterinarian makes the diagnosis from the examination and the DNA result.

Übertragung

Seven diseases are recessive: SCID, LFS, CA, GBED, HERDA, CM and WFFS. A foal is affected only if it gets one copy from each parent. A horse with one copy is a healthy carrier.

Carrier x clear gives 50% carriers, no affected foals
Carrier x carrier gives 25% clear, 50% carriers, 25% affected

Three are dominant: PSSM1, HYPP and MH. One copy is enough to make a horse susceptible.

One copy x clear gives 50% clear, 50% susceptible
One copy x one copy gives 25% clear, 50% one copy, 25% two copies

Each disease is inherited separately. None of the genes is on a sex chromosome, so colts and fillies are affected equally.

Prävention

Preventing affected foals.

Never mate two carriers of the same recessive disease
A carrier mated only to partners that tested clear produces no affected foals, so good bloodlines can stay in use while the variant is bred out
Breeding a horse positive for PSSM1, HYPP or MH passes the risk on to its foals
Test the partner too: the panel shows which of the ten diseases matter for each mating

Looking after a positive horse. A horse positive for PSSM1, HYPP or MH needs a plan made with your veterinarian: feeding and exercise for PSSM1 and HYPP, and precautions before any anaesthesia for MH. Tell your veterinarian the result before any operation.

Ergebnisse

Ein DNA-Freiwilligkeitszertifikatwird ausgestellt, das den genetischen Status des Pferdes für die folgenden Störungen angibt: SCID, LFS, CA, PSSM1, HYPP, GBED, HERDA, MH, CM, WFFS.

Beispielanforderungen

30 bis 40 Haarwurzeln (müssen die Haarzwiebel enthalten) oder 5 ml Blut in einem K3-EDTA-Röhrchen.

Bearbeitungszeit

Standardbearbeitung– Ergebnisse innerhalb von 5 bis 10 Werktagennach Probeneingang im Labor.

Wie es funktioniert

🛒 Test kaufen: Wählen Sie den Test aus und kaufen Sie ihn online.

📧 Anleitung erhalten: Nach der Zahlungsbestätigung erhalten Sie die Anleitung zur Probenentnahme per E-Mail.

📄 Formular ausfüllen: Drucken Sie das Einsendeformular aus und füllen Sie es mit den Identifikationsdaten des Tieres aus.

✨ Probe entnehmen: Ziehen Sie 20 bis 40 Haare mit Haarwurzel (Bulbus) aus und kleben Sie sie in das markierte Feld des Formulars, oder lassen Sie Ihren Tierarzt Blut in ein K3-EDTA-Röhrchen entnehmen.

📮 An das Labor senden: Equigerminal, S.A., HIESE, Rua da Quinta do Sobreiro, 25, Quinta Vale do Espinhal, 3230-343 Penela, PORTUGAL.

📊 Befund erhalten: Der zertifizierte Befund wird ausgestellt, sobald die Analyse validiert ist.

Häufig gestellte Fragen

At what age can a horse be tested?
Any age. The genotypes are fixed at conception, so one test lasts for life.

What is not included?
Lethal White Foal Syndrome (frame overo), coat colour genes and the MIM (PSSM2) panel. MIM is sold separately, and the link between its variants and disease has not been confirmed by independent research.

For Professionals

Genetic and clinical detail for veterinarians, geneticists and laboratories.

Loci genotyped (gene, variant, inheritance). Full HGVS, identifiers, classification, frequencies and references are on each individual test page.

SCID: PRKDC (ECA9), NM_001163858.1:c.9478_9482del, p.(Asn3160fs*3); autosomal recessive.
LFS: MYO5A (ECA1), XM_023617258.1:c.4249del (published c.4459delC); autosomal recessive.
CA: TOE1 exon 4, near MUTYH (ECA2), XM_001496197.5:c.284G>A, p.(Arg95His); autosomal recessive; associated, not proven causal.
PSSM1: GYS1 (ECA10), NM_001126125.2:c.926G>A, p.(Arg309His); autosomal incomplete dominant.
HYPP: SCN4A (ECA11), NM_001081761.1:c.4248C>G, p.(Phe1416Leu); autosomal incomplete dominant.
GBED: GBE1 (ECA26), NM_001081940.2:c.102C>A, p.(Tyr34*); autosomal recessive, lethal.
HERDA: PPIB (ECA1), NM_001099761.1:c.115G>A, p.(Gly39Arg) (also G6R); autosomal recessive.
MH: RYR1 (ECA10), XM_023649662.1:c.7363C>G, p.(Arg2455Gly) (published c.7360C>G, R2454G); autosomal dominant.
CM: CLCN1 (ECA4), XM_001915636.4:c.1775A>C, p.(Asp592Ala); autosomal recessive.
WFFS: PLOD1 (ECA2), XM_001491331.6:c.2032G>A, p.(Gly678Arg); autosomal recessive.

Variant classification: ISAG/AVCG Pathogenic (P) per OMIA for GYS1 R309H and GBE1 c.102C>A; the other eight are not currently evaluated.
Breeds: SCID and LFS in Arabians and part-bred Arabians, LFS concentrated in Egyptian Arabian lines. CA in the Arab, Bashkir Curly, Icelandic Horse, Quarter Horse, Trakehner and Welsh Pony, mostly through Arabian ancestry. PSSM1 in Quarter Horses, Paints, Appaloosas, draft breeds, some Warmbloods and other breeds. HYPP in Quarter Horses, Paints, Appaloosas and their crosses. GBED in Quarter Horses and Paints. HERDA in Quarter Horses, Paints and Appaloosas. MH in Quarter Horses and related breeds. CM described in New Forest ponies. WFFS described in Warmbloods, reported less often in other breeds.