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Cremeverdünnung

Name: Cremeverdünnung
Brand: Equigerminal
Price: 43.05 EUR

Das Cream-Dilution-Gen hat unterschiedliche Auswirkungen auf verschiedene Grundfarben. Um die genaue „Typenbezeichnung“ des Cream Dilute des Pferdes zu erhalten, wird...

€43.05 Inkl. MwSt

Über den Test

Das Cream-Dilution-Gen hat unterschiedliche Auswirkungen auf verschiedene Grundfarben.

Um den genauen „Typnamen“ der Cream-Aufhellung des Pferdes zu erhalten, wird empfohlen, diesen Test in Verbindung mit den Genen Extension und Agouti durchzuführen.

Warum testen?

Ein Test ist sinnvoll, wenn eine genetische Bestätigung erforderlich ist oder um Creme-Dilute-Pferde von anderen Genen mit ähnlichen Auswirkungen (wie Champagne-Dilution und Schimmel) abzugrenzen.

Die Durchführung dieses Tests bestätigt, ob ein Pferd Creme-Dilute ist. Wie erwähnt, hat das Creme-Dilution-Gen unterschiedliche Auswirkungen auf verschiedene Grundfarben. Um den genauen „Typnamen“ der Creme-Dilution des Pferdes zu erhalten (z. B.Buckskin,Palomino,Cremello…), wird empfohlen, diesen Test in Verbindung mit Red Factor und Agouti durchzuführen.

Klinische Zeichen

Cream lightens the coat. How it looks depends on the base colour and on the number of copies. With no copy, the base colour shows as it is.

One copy: red pigment lightened.

Chestnut becomes palomino: a golden body with a white or flaxen mane and tail
Bay becomes buckskin: a golden body with the black points kept
Black becomes smoky black, which usually looks like an ordinary black

Two copies: red and black pigment lightened. The coat goes pale cream, the skin is pink and the eyes are blue.

Chestnut becomes cremello
Bay becomes perlino: a cream body with slightly darker, rust-tinged points
Black becomes smoky cream

What fools the eye:

Smoky black read as black. This is the commonest mistake with this gene.
Palomino read as flaxen chestnut, and the other way round
Cremello or perlino read as white or albino. These horses have cream hair and still make a little pigment. True white horses owe their colour to other genes.
Buckskin read as bay dun, or the two present together
Grey, which slowly strips any of these colours away

Health. No disease is linked to Cream. Blue eyes and pink skin are part of the colour, not a defect, and need no treatment.

Übertragung

Cream shows with one copy, and shows more with two. The gene is not on a sex chromosome, so colts and fillies are the same.

What each mating can produce:

N/N x N/N gives 100% N/N
N/N x N/Cr gives 50% N/N, 50% N/Cr
N/N x Cr/Cr gives 100% N/Cr
N/Cr x N/Cr gives 25% N/N, 50% N/Cr, 25% Cr/Cr
N/Cr x Cr/Cr gives 50% N/Cr, 50% Cr/Cr
Cr/Cr x Cr/Cr gives 100% Cr/Cr

Prävention

The result lets you plan which dilute colours a mating can give.

To guarantee a dilute foal. Use a parent with two copies.

To get a palomino. The foal needs one Cream copy on a chestnut base. Cremello put to chestnut gives only palominos.

To get a buckskin. The foal needs one Cream copy on a bay base. Cremello put to bay is the most efficient route, and the outcome then depends on the bay parent's own base colour genes.

To avoid a double dilute. Mate a Cream carrier only with a partner that tested negative.

Ergebnisse

Der DNA-Test bestätigt das Vorhandensein des Cream-Dilutionsgens und stellt die Ergebnisse wie folgt dar:

N/- Nicht verdünnt. Die Grundfarben sind schwarz, braun oder fuchsfarben, in Ermangelung anderer modifizierender Gene.
N/Cr– Verdünnt. Heterozygot, eine Kopie des Cream (Cr)-Allels. Fuchswird zu Palominoverdünnt; Braunwird zu Buckskinund Schwarzwird zu Smoky Blackverdünnt. Diese Farben können durch die Wirkung anderer Gene weiter modifiziert werden.
Cr/- Doppelt verdünnt, zwei Kopien des Cream (Cr)-Allels. Fuchs wird zu Cremelloverdünnt; Braun wird zu Perlinound Schwarz wird zu Smoky Cream

Beispielanforderungen

30 bis 40 – Haarwurzeln – Umschlag oder 5 ml – Blut – K3 EDTA-Röhrchen

Bearbeitungszeit

2 bis 5 Werktage

Wie es funktioniert

🛒 Test kaufen: Wählen Sie den Test aus und kaufen Sie ihn online.

📧 Anleitung erhalten: Nach der Zahlungsbestätigung erhalten Sie die Anleitung zur Probenentnahme per E-Mail.

📄 Formular ausfüllen: Drucken Sie das Einsendeformular aus und füllen Sie es mit den Identifikationsdaten des Tieres aus.

✨ Probe entnehmen: Ziehen Sie 20 bis 40 Haare mit Haarwurzel (Bulbus) aus und kleben Sie sie in das markierte Feld des Formulars, oder lassen Sie Ihren Tierarzt Blut in ein K3-EDTA-Röhrchen entnehmen.

📮 An das Labor senden: Equigerminal, S.A., HIESE, Rua da Quinta do Sobreiro, 25, Quinta Vale do Espinhal, 3230-343 Penela, PORTUGAL.

📊 Befund erhalten: Der zertifizierte Befund wird ausgestellt, sobald die Analyse validiert ist.

Häufig gestellte Fragen

What does this test not detect?
It reads Cream only. It does not read Pearl, Sunshine or Snowdrop, three other dilutions in the same gene. It does not test Champagne, Silver, Dun, Grey, Mushroom, any white pattern or the base colour. It says nothing about health, performance or temperament.

At what age can a horse be tested?
Any age. The genotype is fixed at conception and never changes. A foal coat is a poor guide to dilution, so testing early makes sense.

Should I also test for Pearl?
Yes, if the horse is pale and the Cream result does not explain it, or if it is of Iberian or stock-horse origin, where Pearl occurs and can imitate Cream. Where relevant, test Champagne too.

For Professionals

Genetic and clinical detail for veterinarians, geneticists and laboratories.

Gene / locus: SLC45A2 (solute carrier family 45 member 2; formerly MATP), Cream (C) locus, ECA21.
Variant: C^Cr allele, missense. HGVS (EquCab3.0): NC_009164.3:g.31690653G>A; XM_001498110.4:c.601G>A; XP_001498160.2:p.(Asp201Asn).
Alternative designations: published as exon 2 c.457G>A, p.Asp153Asn (Mariat et al., 2003). The genomic position is the same; c. and p. numbering differ because OMIA uses a more recent RefSeq transcript.
Variant identifiers: rs1140980396 (EVA); OMIA variant 153.
Variant classification: not currently evaluated (ISAG/AVCG, per OMIA).
Mechanism: SLC45A2 encodes a transporter the melanocyte needs to function; the Cream variant reduces the pigment deposited in the hair.
Inheritance: autosomal incomplete dominant (dosage effect): one copy dilutes phaeomelanin, two copies dilute phaeomelanin and eumelanin. OMIA code: A (autosomal).
Breeds with documented carriers or cases: OMIA variant record lists Quarter Horse, Morgan and Welsh Pony. Avila et al. (2022) found Cream in 25 of 28 breeds: Andalusian, Appaloosa, Arabian, Connemara Pony, Dutch Warmblood, Gypsy Cob, Gypsy Vanner, Icelandic Horse, Lusitano, Miniature Horse, Missouri Fox Trotter, Morgan Horse, Mustang, Norwegian Fjord Horse, Oldenburg, Paint Horse, Pony of the Americas, Pura Raza Espanola, Quarter Horse, Rocky Mountain Horse, Shetland Pony, Standardbred, Tennessee Walking Horse, Thoroughbred and Welsh Pony. Not detected in Hanoverian (n=31), Knabstrupper (n=71) or Percheron (n=37); absence in a sample does not prove absence in the breed.
Allele / carrier frequencies: allele frequency from 42% in the Lusitano (n=102) to 1.3% in the Standardbred (n=39), Iberian breeds among the highest (Avila et al., 2022; 11,281 horses tested, 6,878 after removing close relatives). The authors note ascertainment bias, as samples were submitted for colour testing, so figures for less-sampled breeds may be overestimated.
Clinical / diagnostic notes for veterinarians: SLC45A2 carries at least four equine dilution alleles: Cream, Pearl (Sevane et al., 2019), Sunshine (Holl et al., 2019) and Snowdrop (Bisbee et al., 2020).

Key references:

Mariat D, Taourit S, Guerin G (2003). A mutation in the MATP gene causes the cream coat colour in the horse. Genet Sel Evol 35:119-133. doi:10.1051/gse:2002039. PMID 12605854.
Locke MM, Ruth LS, Millon LV, Penedo MCT, Murray JD, Bowling AT (2001). The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21. Anim Genet 32:340-343.
Holl HM, Pflug KM, Yates KM, Hoefs-Martin K, Shepard C, Cook DG, Lafayette C, Brooks SA (2019). A candidate gene approach identifies variants in SLC45A2 that explain dilute phenotypes, pearl and sunshine, in compound heterozygote horses. Anim Genet 50:271-274. doi:10.1111/age.12790. PMID 31006892.
Avila F, Hughes SS, Magdesian KG, Penedo MCT, Bellone RR (2022). Breed distribution and allele frequencies of base coat color, dilution, and white patterning variants across 28 horse breeds. Genes 13:1641.