MIM (PSSM2) DNA Test
Ensure the Health and Performance of Your Horses with Accurate MIM Testing. Our DNA test identifies the presence of genetic variants associated with Muscle Integrity Myopathy (MIM), formerly known as PSSM2, which affects muscle function and structure.
Sample Requirements
- 30 to 40 hair roots - envelope
- Alternatively, 5 mL blood - K3 EDTA tube
Turnaround Time
Results Description
The DNA test identifies six genetic variants that predispose horses to developing symptoms of Muscle Integrity Myopathy:
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P2: Myotilinopathy
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P3: Filaminopathy
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P4: Myozenin-3-Myopathy
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P8: PYROXD1-Myopathy
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Px: CACNA2D3-Myopathy
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K1: COL6A3-Myopathy
Genetic Inheritance
Muscle Integrity Myopathy (MIM) is caused by a hereditary predisposition involving multiple genetic variants. These variants disrupt the structure and function of muscle fibers, leading to symptoms such as muscle stiffness, unexplained lameness, and difficulty building muscle.
Clinical Signs and Affected Breeds
Symptoms of MIM can vary widely among horses and include unexplained lameness, muscle stiffness, difficulty with gait changes, reluctance to move, muscle atrophy, and behavioral changes. Almost any breed can be affected, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds.
Why Test?
Testing for MIM is crucial for breeders and owners to make informed decisions. By identifying carriers of the genetic variants, breeding choices can be optimized to prevent the spread of these disorders. Additionally, knowing a horse's genetic status can help manage and mitigate symptoms through tailored exercise and feeding protocols.
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Detailed Results Description
The DNA test results will indicate the presence of the following genetic variants:
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P2: Myotilinopathy
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P3: Filaminopathy
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P4: Myozenin-3-Myopathy
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P8: PYROXD1-Myopathy
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Px: CACNA2D3-Myopathy
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K1: COL6A3-Myopathy
Additional Information
Muscle Integrity Myopathy (MIM) is a genetic disorder that disrupts muscle function and structure, leading to various clinical signs. While it is not possible to cure genetic disorders, optimized management through diet and exercise can help mitigate symptoms, allowing horses to lead normal lives.
References
Generatio.
Muscle Integrity Myopathy in HorsesEquiSeq.
Polysaccharide Storage Myopathy type 2 (PSSM2)
FAQs
What breeds are affected by MIM?
Almost any breed can be affected by MIM, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds.
How is MIM inherited?
MIM is caused by multiple genetic variants that disrupt muscle structure and function. These variants are inherited and can predispose horses to developing symptoms of exertional myopathy.
How can MIM be managed?
While genetic disorders cannot be cured, their symptoms can often be managed through optimized feeding and exercise protocols. Identifying genetic variants through testing allows for tailored management strategies to mitigate symptoms.
Visit our full FAQ page for more details.
